Sit, stay … live longer?
Research shows that a dog’s property can help humans live longer and healthier. Now, a United States biotechnology company wants to return the favor with anti-aging drug designed to expand the life of your canine companion.
“The space of longevity is full of people right now and, for a good reason,” The Post Celine Haliooua, founder and CEO of Loyal, told The Post Celine Haliooua. “We all want to find out how to get happier and healthier years for our loved ones, especially hairy ones.”
Before launching Loyal in 2019, Haliooua worked in treatments for neurodegenerative diseases in humans, conditions that, like dog aging, have no preventive drug.
“This combination of experience led to my mission to develop the first medicine approved for a healthy extent of life,” he said.
Good boys, great science
Loyal has three longevity drugs in pipeline, including two that are specifically aimed at larger breeds, which usually have a much shorter life.
Although small dogs like Chihuahuas can live for 18 years or more, giant races like the great Danes would be lucky enough to do it up to 10.
It is there that Loy-001 and Loy-003 enter. These drugs are aimed at dogs of 7 years and more that weigh at least 40 pounds.
They work by reducing the levels of insulin-like growth (IGF-1), a hormone that feeds the growth of cells. Scientists believe that high levels of IGF-1 reduce the life of large dogs, which can have up to 28 times more hormone than smaller breeds.
A version, Loy-001, is injectable given a few times a year to the veterinarian. The other, Loy-003, is a daily chewable pill.
The two drugs are currently in pilot studies, and Loyal is seeking the approval of the Conditional FDA by 2027.
Loyal’s third drug drug, Loy-002, is even more developed. The treatment aims at dogs over 10 years and more that weigh at least 14 pounds.
It is currently being tested in a large-scale clinical trial that includes more than 1,200 dogs into 70 clinics, making it one of the largest studies in veterinary history, according to Halioua.
The drug works by directing metabolism: the complex system of chemical reactions that feeds essential functions such as breaking food, producing energy and repairing cells.
As metabolism slows down with age, it can lead to insulin resistance and trigger various health problems in both humans and dogs, including cognitive decay, osteoarthritis and cancer.
“Improving metabolic health is one of the best -rated routes to expand life and health,” Haliooua said.
“Search [shows] It can improve health and reduce the risk of age -related diseases between species, from mice to humans, “he added.
So far, things look like PAWs activities. A pilot study of 48 dogs did not show adverse effects after three months of Loy -002.
Loyalty he told The Guardian earlier that he hopes that the drug can add at least one more year to a dog’s life, and that they will also be healthier during this time.
Once approved, Halioua hopes that Loy -002 will become a common preventive tool, such as flea and tick medication.
“We hope that all dogs will benefit from their ability to protect and even reverse, some of the harmful effects of metabolic dysfunction,” he said.
Loyal predicts that the drug will receive conditional approval by the FDA by 2026.
But dogs are not the only ones that could benefit.
“We are in a good way to develop the first medicine approved by the FDA for longevity, for any species,” Haliooua said.
“Dogs share our environments and develop diseases significantly related to age in similar stages of life, making them valuable models for human health and scientific research,” he added.
Dogs also make us healthier
Haliooua’s lifelong love is thoroughly.
“I have always surrounded myself with animals, growing, my family had 15 pets and rehabilitated wild animals,” he said. “My rottweiler, della, is always by my side and is an important influence on the work I do.”
It turns out that dogs not only provide love, but also could bring health benefits.
Studies show that dogs can alleviate loneliness, stress and anxiety. It was even found that only 10 minutes of doing a little can significantly reduce cortisol levels, the main stress hormone.
Even blocking your eyes with your dog gives a boost to the brain. A 2009 Japanese study found that looking at his eyes lifts oxytocin: “loving hormone” linked to bonding and happiness.
Dogs can even help -you live longer. A broad review of the investigation from 1950 to 2019 found that dog owners have a lower risk of death compared to those who do not have pets.
It is not an accident. Research shows that dog owners often have lower blood pressure, cholesterol and a small risk of heart disease. In addition, they obtain more exercise, which builds muscle, strengthens the bones and joints and maintains the weight in control.
This is no coincidence. Dog owners usually have lower blood pressure, cholesterol and less risk of heart disease. In addition, they are more active: walking their dogs regularly strengthens muscles, bones and joints and helps maintain control in control.
Some research even linking the ownership of larger brains and stronger thought, with faster processing and better memory.
And here is the kicker: An important study found that a dog reduces the risk of dementia: a profit that is not shared by cats owners.
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